4-Repeat Tauopathy Neuroimaging Initiative (4RTNI)
The 4RTNI was a longitudinal observational neuroimaging study involving approximately 322 participants from the United States. Participants were recruited between 2011 and 2024 through various academic medical centres, including the University of California San Francisco UCSF, Johns Hopkins University, and the Mayo Clinic. The cohort includes individuals diagnosed with corticobasal syndrome (CBS), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and healthy volunteers aged between 40 and 80 years. Additional participants were recruited in a subsequent second cycle in 2016 to include more diverse clinical presentations. Participants underwent follow-up assessments every 6 to 12 months.
Study design
Cohort
Number of participants at first data collection
322 (participants as of April 2023)
Age at first data collection
40 - 80 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2011 (cycle 1 participants)
2016 (cycle 2 participants)
Primary Institutions
University of California, San Francisco (UCSF)
Profile paper DOI
Not available
Funders
National Institute on Aging (NIA)
National Institutes of Health (NIH)
Ongoing?
No
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Magnetic Resonance Imaging (MRI)
- Positron Emission Tomography (PET)
- None
Engagement
Keywords
Consortia and dataset groups
