Alzheimer Biomarkers Consortium - Down Syndrome (ABC-DS)
The ABC-DS study follows adults with Down syndrome (DS) to identify early biomarkers of Alzheimer's disease (AD). Since the study began in 2015, over 500 participants have been recruited, and recruitment is ongoing. Participants are individuals with DS aged 25 years and older, who have been recruited from the United States of America (California, New York, Massachusetts, Kentucky, Missouri, Wisconsin and Pennsylvania) and the United Kingdom (Cambridge). The study has also recruited a small number of healthy non-DS sibling participants as controls. Participants are followed up at approximately 16-month intervals for a total of 3 to 4 cycles.
Study design
Cohort - clinical
Number of participants at first data collection
519 (participants with DS)
~40 (sibling controls)
Recruitment is ongoing
Age at first data collection
≥ 25 years (participants with DS)
≥ 25 years (sibling controls)
Participant year of birth
Varied (participants with DS)
Varied (sibling controls)
Participant sex
All
Representative sample at baseline?
No
Sample features
Countries
Year of first data collection
2015
Primary Institutions
University of California, Irvine (UCI)
University of Pittsburgh
University of Wisconsin-Madison
Profile paper DOI
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE)
National Institute on Aging (NIA)
National Institutes of Health (NIH)
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Interview – face-to-face
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Self-completed questionnaire – paper or computer assisted
- None
- Magnetic Resonance Imaging (MRI)
- Positron Emission Tomography (PET)
- None
Engagement
Keywords
Consortia and dataset groups
