Alzheimer's and Families study (ALFA)
The ALFA project was established in 2013 to investigate pathophysiological changes in pre-clinical Alzheimer’s disease (AD). It has prospectively followed cognitively unimpaired late- and middle-aged participants, most of whom are adult children of AD patients. Participants are cognitively unimpaired Spanish and/or Catalan-speaking persons aged between 45 and 74 years. Over 2,700 people were enrolled at baseline. A subset of 450 participants of the ALFA parent cohort were recruited and underwent a nested longitudinal long-term study, named the ALFA+ study.
Study design
Cohort
Number of participants at first data collection
2,743 (participants)
Age at first data collection
45 - 74 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2013
Primary Institutions
Barcelonaβeta Brain Research Center
Fundación Pasqual Maragall
Profile paper DOI
Funders
Carlos III Health Institute (Instituto de Salud Carlos III, ISCIII)
Pasqual Maragall Foundation (FPM)
”la Caixa” Foundation
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Functional magnetic resonance imaging (fMRI)
- Magnetic Resonance Imaging (MRI)
- Positron Emission Tomography (PET)
- None
Engagement
Keywords
Consortia and dataset groups
