Arizona APOE4 Gene Dose Program
The Arizona APOE4 Gene Dose Program provides a longitudinal cohort of over 800 research participants with two, one, and no copies of the APOE4 gene, reflecting three levels of genetic risk for Alzheimer's disease (AD), including a sub-set of subjects with extensive brain imaging and other biomarker data. Participants are cognitively unimpaired and are followed every two years.
Study design
Cohort
Number of participants at first data collection
861 (participants)
Age at first data collection
Varied (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
1994
Primary Institutions
Banner Health
Mayo Clinic
Links
Profile paper DOI
Not available
Funders
National Institute on Aging (NIA)
State Government of Arizona
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Interview – face-to-face
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Diffusion Tensor Imaging (DTI)
- Magnetic Resonance Imaging (MRI)
- Positron Emission Tomography (PET)
- None
Engagement
Keywords
Consortia and dataset groups
