As an extension of BioFINDER One, BioFINDER Two follows a new cohort of individuals with and without cognitive decline, impairment or dementias. BioFINDER Two follows both middle-aged participants and elderly participants. The cohort includes five sub-cohorts. Cohort A: 300 cognitively healthy middle-aged participants (40-65 years) as well as 40 participants aged 20-40 years; Cohort B: 300 cognitively healthy elderly participants (65-100 years); Cohort C: 800 participants with either subjective cognitive decline or mild cognitive impairment (40-100 years); Cohort D: 400 participants with mild to moderate dementia due to Alzheimer’s disease (40-100 years); and Cohort E: over 500 participants with primary neurodegenerative disorders other than Alzheimer’s disease (40-100 years). All participants are fluent in Swedish, some Cohort A and B participants are also in the Malmö Offspring study and Cohort C, D and E participants were recruited from the Skåne University Hospital and Ängelholm Hospital in southern Sweden. This has resulted in 2,550 participants and each group is followed up every 1-2 years, for 2, 6 or 8 years.

Recruitment is ongoing