Brain disconnectome mapping derived from white matter lesions and serum neurofilament light levels in multiple sclerosis: A longitudinal multicenter study
A total of 328 multiple sclerosis patients were prospectively enrolled at four European multiple sclerosis centres from July 2016 to December 2017 (68 subjects from Hospital Clinic of Barcelona, Spain; 95 subjects from Oslo University Hospital, Norway; 73 subjects from Charité-Universitaetsmedizin Berlin, Germany; 92 subjects from Ospedale Policlinico San Martino, Genoa, Italy). All multiple sclerosis patients were invited for a two-year follow-up between January 2017 and March 2020, resulting in 280 subjects (85 %) completing the longitudinal study.
Study design
Cohort - clinical
Number of participants at first data collection
328 (participants)
Age at first data collection
18 – 80 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Countries
Year of first data collection
2016
Primary Institutions
Charité – Berlin University Medicine (Charité – Universitätsmedizin Berlin) (Healthcare/Medical, Germany)
Hospital Clinic of Barcelona (Hospital Clínico de Barcelona) (Healthcare/Medical, Spain)
Oslo University Hospital (Oslo universitetssykehus) (Healthcare/Medical, Norway)
Ospedale Policlinico San Martino (Healthcare/Medical, Italy)
Links
No website available
Profile paper DOI
Funders
Biogen Inc. (Industry, United States of America)
Carlos III Health Institute (Instituto de Salud Carlos III, ISCIII) (Research, Spain)
European Commission (Government, Europe)
European Union Horizon 2020 Research and Innovation Program (Research council, European Union)
German Ministry of Science (Deutsches Teilprojekt B Förderkennzeichen) (Government, Germany)
Ongoing?
Yes
Data types collected
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Magnetic Resonance Imaging (MRI)
- None
Engagement
Keywords
