Brain Structure, Function, and Growth in Children with Oral Cleft
The purpose of this study is to examine brain development in subjects with isolated cleft lip and/or cleft palate (iCL/P) when compared to unaffected controls using an accelerated longitudinal design. Participants assessed during the first funding period (November 2002 to June 2007) were between 7 and 17 years old. A total of 232 participants (130 unaffected and 102 with iCL/P) were assessed during this phase. The second funding period (March 2009 to February 2013) permitted return assessments for the original participants, recruited additional participants, and extended the age range to 27 years old.
Study design
Cohort - accelerated
Number of participants at first data collection
208 (participants)
Age at first data collection
7 - 17 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2002
Primary Institutions
University of Iowa
Profile paper DOI
Funders
National Institute of Dental and Craniofacial Research (NIDCR)
National Institutes of Health (NIH)
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Magnetic Resonance Imaging (MRI)
- None
Engagement
Keywords
