The study was designed to investigate the impact of job and work loss on mental and physical well-being during the COVID-19 pandemic and associated lockdowns. The sample comprises people living in Australia aged at least 18 who were employed in a paid job or self-employed before the pandemic. The resulting baseline cohort of over 2,500 participants came from a diverse set of industries, occupations, and working conditions across all states and territories in Australia. Participants were followed up at one, three, and six months after the baseline survey. Of the individuals who remained at work during the pandemic, 53.3% were female, and of the non-working participants, 72.9% were female.