ChiLdhood Arthritis Risk factor Identification sTudY (CLARITY)
CLARITY is a biobank of children with and without Juvenile Idiopathic Arthritis (JIA) established to identify genomic and environmental disease risk factors for developing JIA. CLARITY also seeks to understand the differences in the natural disease progression in children with JIA and responses to treatments. Cases were recruited from public or private clinics at the Royal Children's Hospital (RCH) in Melbourne, Australia, diagnosed with JIA by a paediatric rheumatologist before 16 years of age. Controls are recruited from the RCH Day Surgery Unit attending for minor surgical procedures. As of July 2019, 1,470 children (710 cases and 760 controls) were included in the biobank, which is now being expanded to include children all around Australia.
Study design
Cohort, Biobank
Number of participants at first data collection
1,470 (participants as of July 2019)
Recruitment is ongoing
Age at first data collection
Birth - 19 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2008
Primary Institutions
Murdoch Children’s Research Institute (MCRI)
Royal Children's Hospital (RCH)
Profile paper DOI
Funders
ANZ Charitable Trust
Arthritis Australia
Australian Academy of Science
Australian Research Council (ARC)
Equity Trustees Lynne Quayle Charitable Trust Fund
Ongoing?
Yes
Data types collected
- Interview – face-to-face
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Secondary data
- Self-report questionnaire – online
- None
- None
- Healthcare data
Engagement
Keywords
