Clinical and Immunological Investigations of Subtypes of Autism

Sample details

This study aimed to understand autism spectrum disorder (ASD) and its subtypes. The study recruited 106 children diagnosed with ASD, 25 with significantly impaired cognitive ability but without ASD, categorised as the non-ASD developmental delay (DD) group, and 70 children with no behavioural or psychological concerns, categorised as the typical development (TYP) group. Participants were aged two to six years and were recruited from Washington, DC and the Bethesda, Maryland area in the United States of America. Visits before participants' third birthday were spaced at six-month intervals, and later visits were annual until the child completed at least three years of participation or until the child’s fifth birthday. The study was conducted between 2006 and 2014.

Study design
Cohort

Number of participants at first data collection

106 (ASD group participants)

25 (DD group participants)

70 (TYP group participants)

Age at first data collection

2 - 6 years (ASD group participants)

2 - 6 years (DD group participants)

2 - 6 years (TYP group participants)

Participant year of birth

Varied (ASD group participants)

Varied (DD group participants)

Varied (TYP group participants)

Participant sex
All

Representative sample at baseline?
No

Sample features

Autism Spectrum Disorder (ASD)

Children and young people

Developmental disability

Typically developing

Dataset details

Country

United States of America

Year of first data collection

2006

Primary Institutions

National Institute of Mental Health (NIMH)

Links

clinicaltrials.gov/study/NCT00298246

nda.nih.gov/edit_collection.html

doi.org/10.1212/WNL.0000000000005759

doi.org/10.1186/s11689-017-9222-9

Profile paper DOI

doi.org/10.1016/j.ebiom.2015.11.004

Funders

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

National Institute of Mental Health (NIMH)

Ongoing?
No

Data types collected

Quantitative data collection

Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
Interview – unspecified
Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
Self-report questionnaire – unspecified

Qualitative data collection