The CNICS is a United States of America-based, clinic-integrated cohort study established to investigate long-term clinical outcomes among people living with human immunodeficiency virus (HIV) in the era of highly active antiretroviral therapy (HAART). As of 2024, it comprises over 49,000 HIV-infected adults receiving care at seven academic medical centres across the country. Participants were recruited from routine clinical care at CNICS-affiliated sites beginning in 1995, with ongoing enrollment of approximately 1,400 new patients annually to reflect the evolving HIV epidemic and treatment landscape. Recruitment has expanded over time to include additional Centers for AIDS Research Network (CFAR) sites such as Johns Hopkins University, enhancing geographic and ethnic representation. Participants are followed through routine clinical visits, typically every three months, with data captured prospectively via electronic medical records and supplemented by patient-reported outcomes collected approximately every six months.

Recruitment is ongoing