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Colombo Twin and Singleton Study (CoTASS)
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Sample details

CoTASS is a population-based cohort study of twins and singletons from the Colombo district of Sri Lanka. The cohort of twins aged over 15 were randomly selected from the Colombo twin register; the Colombo component of the Sri Lankan Twin Registry (SLTR). A total of 3,980 twin individuals (including 1,954 twin pairs, 72 unpaired twins, and 5 sets of triplets) were enrolled from the register and completed baseline in 2005. Among the twin individuals, the mean age was 34 years, 46.2% were male, and 90.1% were of Sinhalese ethnicity. The non-twin sample comprised 2,019 singletons who were randomly selected from the geographical areas where twins were identified. In the non-twin cohort, the mean age was 43.5 years and 45.6% were male.

Study design
Cohort - twin

Number of participants at first data collection

3,980 (twin individuals)

2,019 (non-twin participants)

Age at first data collection

15 - 84 years (twin individuals)

≥15 years (non-twin participants)

Participant year of birth

Varied (twin individuals)

Varied (non-twin participants)

Participant sex
All

Representative sample at baseline?
The Colombo district of Sri Lanka

Sample features

Adults
Dizygotic and monozygotic twins
Population-based sample
Triplets
Two cohorts
Dataset details

Country

Sri Lanka

Year of first data collection

2005

Primary Institutions

Institute for Research and Development

King's College London (KCL)

Links

sltr.ird.lk/project/colombo-twin-and-singleton-study/

ird.lk/wpll-project/colombo-twin-and-singleton-study/

doi.org/10.1186/s12889-017-4992-2

Funders

Medical Research Council (MRC)

National Health and Medical Research Council (NHMRC)

Wellcome Trust

Ongoing?
Yes

Data types collected

mentalHealthData
Quantitative data collection
  • Interview – face-to-face
  • Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
Qualitative data collection
  • None
Neuroimaging data collection
  • None
Linked or secondary data
  • None
Features

Engagement

  • Patients, service users, lived experience involvement
  • Community engagement
  • Keywords

    Anxiety
    Biological samples/biospecimens
    Depression
    Environmental exposures
    Epidemiology
    Gene-environment interactions (GxE)
    Health behaviour
    Mental health
    Psychiatry
    Sibling relationships
    Somatic symptoms
    Stressful life events

    Consortia and dataset groups

    Sri Lankan Twin Registry (SLTR)
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