Dominantly Inherited Alzheimer Network Observational Study (DIAN)
DIAN is an international, multicenter registry of individuals who are biological adult children of a parent with a known causative mutation for Alzheimer's Disease. The participants are classified as symptomatic or asymptomatic for Alzheimer's symptoms, and those who are either symptomatic or asymptomatic and not 5 years older than estimated age of symptom onset are seen in-person yearly. Those who are asymptomatic and over 5 years older than estimated age at onset participate with annual remote visits (phone calls). The target sample size of DIAN is 850 participants.
Study design
Cohort, Biobank
Number of participants at first data collection
255 (participants)
Recruitment is ongoing
Age at first data collection
≥ 18 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Countries
Year of first data collection
2009
Primary Institutions
Washington University in St. Louis (WashU)
Links
dian.wustl.edu/our-research/observational-study/
Profile paper DOI
Funders
Japan Agency for Medical Research and Development (AMED)
F. Simmons and O. Mohan Fund
German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE)
Korea Dementia Research Center (KDRC)
Korea Health Industry Development Institute (KHIDI)
Ongoing?
Yes
Data types collected
- Interview – face-to-face
- Interview – phone
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Magnetic Resonance Imaging (MRI)
- Positron Emission Tomography (PET)
- None
Engagement
Keywords
