Dominantly Inherited Alzheimer Network Observational Study (DIAN)
DIAN is an international, multicentre registry of individuals who are biological adult children of a parent with a known causative mutation for Alzheimer's Disease. The participants are classified as symptomatic or asymptomatic for Alzheimer's symptoms, and those who are either symptomatic or asymptomatic and not 5 years older than the estimated age of symptom onset are seen in-person yearly. Asymptomatic individuals who are older than the estimated age at onset by 5 years participate in annual remote visits (phone calls). The target sample size of DIAN is 850 participants.
Study design
Cohort, Biobank
Number of participants at first data collection
255 (participants)
Recruitment is ongoing
Age at first data collection
≥ 18 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Countries
Year of first data collection
2009
Primary Institutions
Washington University in St. Louis (WashU) (Academic, United States of America)
Profile paper DOI
Funders
F. Simmons and O. Mohan Fund (Third Sector, United States of America)
German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE) (Government, Germany)
Japan Agency for Medical Research and Development (AMED) (Government, Japan)
Korea Dementia Research Center (KDRC) (Research, South Korea)
Korea Health Industry Development Institute (KHIDI) (Government, South Korea)
Ongoing?
Yes
Data types collected
- Interview – face-to-face
- Interview – phone
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Magnetic Resonance Imaging (MRI)
- Positron Emission Tomography (PET)
- None
Engagement
Keywords
