DUtch PARkinson Cohort (DUPARC)
DUPARC is a prospective cohort study of 150 newly diagnosed Parkinson's disease (PD) patients who were treatment-naïve at baseline, to discover and validate biomarkers for PD subtypes, progression and pathophysiology, with particular focus on cognition, gastrointestinal function and vision. Participants were recruited between 2017 and 2020 via a collaborative network of PD treating neurologists in the northern part of the Netherlands. After comprehensive baseline assessments, the patients were re-assessed after 1 year and 3 years, with the intention of an extended follow-up with 3-year intervals.
Study design
Biobank, Cohort - clinical
Number of participants at first data collection
150 (participants)
Age at first data collection
≥ 18 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2017
Primary Institutions
University Medical Center Groningen (Universitair Medisch Centrum Groningen, UMCG) (Healthcare/Medical, Netherlands)
Profile paper DOI
Funders
W. Garfield Weston Foundation (now known as the Weston Family Foundation) (Third Sector, Canada)
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Arterial Spin Labelling (ASL)
- Diffusion Tensor Imaging (DTI)
- Functional magnetic resonance imaging (fMRI)
- Magnetic Resonance Imaging (MRI)
- Positron Emission Tomography (PET)
- None
Engagement
Keywords
