Early-Course Unmedicated Schizophrenia Patients Exhibit Elevated Prefrontal Connectivity Associated with Longitudinal Change
This study aims to investigate prefrontal cortex connectivity abnormalities in early-course schizophrenia using neuroimaging data from a cohort of 129 unmedicated early-course schizophrenia (EC-SCZ) patients and 106 healthy comparison subjects (HCS) in Chengdu, China. Participants were recruited through the Mental Health Center at West China Hospital and underwent neuroimaging at the Huaxi MR Research Center. All patients received diagnostic confirmation at the 12-month follow-up, with 25 being included in the longitudinal imaging and symptom analysis due to stringent neuroimaging quality criteria and completion of all follow-up assessments.
Study design
Cohort, Cohort - clinical
Number of participants at first data collection
129 (EC-SCZ patients)
106 (HCS)
Age at first data collection
Varied (EC-SCZ patients)
Varied (HCS)
Participant year of birth
Varied (EC-SCZ patients)
Varied (HCS)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
No information available
Primary Institutions
West China Medical Center, Sichuan University (四川大学华西医学中心)
Yale University
Links
reporter.nih.gov/project-details/9245832
scitechdaily.com/onset-schizophrenia-linked-elevated-neural-links/
Profile paper DOI
Funders
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institutes of Health (NIH)
National Natural Science Foundation of China (国家自然科学基金委员会, NSFC)
Ongoing?
Yes
Data types collected
- Interview – face-to-face
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Self-report questionnaire – paper or computer assisted
- None
- Functional magnetic resonance imaging (fMRI)
- Magnetic Resonance Imaging (MRI)
- None
Engagement
Keywords
