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University of North Carolina Early Brain Development Study (EBDS)
University of North Carolina Early Brain Development Study logo
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Sample details

The EBDS aims to study early childhood development and its relationship to cognitive development and risk for psychiatric disorders. Pregnant women with and without schizophrenia and bipolar disorder were recruited from outpatient clinics at UNC Hospitals and Duke University Medical Center in the United States of America. Over 1,000 mother-child dyads were enrolled beginning in 2004 and are being followed longitudinally from birth to age 14 years. So far, participants have been followed up at birth, 1, 2, 4, and 6 years.

Study design
Cohort - birth, Cohort - primary caregiver and child

Number of participants at first data collection

1,134 (mother-child dyads)

Age at first data collection

Birth (children)

Varied (mothers)

Participant year of birth

Varied (children)

Varied (mothers)

Participant sex
All

Representative sample at baseline?
No

Sample features

Children and young people
Control participants
Dizygotic and monozygotic twins
Mother and child dyad
Mothers
Dataset details

Country

United States of America

Year of first data collection

2004

Primary Institutions

Duke University Medical Center

University of North Carolina at Chapel Hill (UNC)

Links

med.unc.edu/psych/research/psychiatry-department-research-programs/early-brain-development-research/

reporter.nih.gov/project-details/9411744

doi.org/10.1038/s41593-023-01501-6

Funders

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

National Institutes of Health (NIH)

Ongoing?
Yes

Data types collected

neuroImagingData
mentalHealthData
Quantitative data collection
  • Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
  • Interview – face-to-face
  • Self-report questionnaire – unspecified
Qualitative data collection
  • None
Neuroimaging data collection
  • Diffusion Tensor Imaging (DTI)
  • Magnetic Resonance Imaging (MRI)
Linked or secondary data
  • None
Features

Engagement

  • None
  • Keywords

    Autism and Autism-like conditions
    Brain development
    Infancy and early childhood
    Magnetic Resonance Imaging (MRI)
    Neurodevelopment
    Neurodevelopmental disorders
    Neuroimaging
    Schizophrenia
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