European Prevention of Alzheimer’s Dementia Longitudinal Cohort Study (EPAD LCS)
EPAD LCS is a prospective, multicentre, pan-European longitudinal cohort study to deeply phenotype individuals at risk of Alzheimer’s dementia (AD) and also to act as a trial-ready cohort for AD prevention trials. The cohort includes over 2,000 participants, recruited mainly from existing parent cohorts in 10 countries across Europe. Participants were over 50 years old, and without a diagnosis of dementia at recruitment in 2016-2019. The participants were followed-up annually to complete a range of comprehensive physical and psychological assessments for up to 4 years.
Study design
Cohort - open, Biobank, Cohort - research programme
Number of participants at first data collection
2,096
Age at first data collection
≥ 50 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Countries
Year of first data collection
2016
Primary Institutions
Barcelonaβeta Brain Research Center
Karolinska Institute (Karolinska Institutet, KI)
University of Cambridge
University of Edinburgh (University o Edinburgh, Oilthigh Dhùn Èideann)
Profile paper DOI
Funders
Innovative Medicines Initiative (IMI)
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Interview – face-to-face
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Secondary data
- None
- Arterial Spin Labelling (ASL)
- Diffusion Tensor Imaging (DTI)
- Functional magnetic resonance imaging (fMRI)
- Magnetic Resonance Imaging (MRI)
- Existing research data
Engagement
Keywords
Consortia and dataset groups
