Family Heart Study (FHS)
The FHS was a multicenter, population-based genetic epidemiology study of coronary heart disease (CHD), involving 3,156 probands and 22,909 of their relatives. Participants were recruited between 1993 and 1995 from four sites in the United States of America: Framingham (MA), Salt Lake City (UT), Minneapolis (MN), and Forsyth County (NC). Recruitment was conducted through 3 parent studies - the Framingham Heart Study, Atherosclerosis Risk in Communities (ARIC), and the Utah Health Family Tree Study - using a combination of random sampling and selection based on family risk scores for CHD. Probands were aged 45 to 69 years, and their relatives aged 25 years or older were invited to participate, resulting in a large, multigenerational cohort. Participants were followed up once, approximately one year after baseline.
Study design
Cohort
Number of participants at first data collection
3,156 (probands)
22,909 (relatives)
Age at first data collection
45 - 69 years (probands)
≥ 25 years (relatives)
Participant year of birth
Varied (probands)
Varied (relatives)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
1993
Primary Institutions
National Heart, Lung, and Blood Institute (NHLBI)
Washington University in St. Louis (WashU)
Links
web.archive.org/web/20230324024257/https://repository.synchros.eu/study/fhs--family-heart-study
Profile paper DOI
Funders
National Heart, Lung, and Blood Institute (NHLBI)
Ongoing?
No
Data types collected
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Secondary data
- Self-report questionnaire – paper or computer assisted
- None
- None
- Existing research data
- Healthcare data
Engagement
Keywords
