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Framingham Heart Study - New Offspring Spouse Cohort (FHS NOS)
Framingham Heart Study - New Offspring Spouse Cohort logo
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Sample details

The FHS began in 1948 and aims to identify common factors or characteristics that contribute to cardiovascular disease. The FHS has been expanded to become a multigenerational study and to include diverse populations so that risk factors in these different groups can be understood. The NOS cohort includes just over 100 participants who were children of the FHS Original cohort, are parents of the Third Generation cohort, and were not previously enrolled in the Offspring cohort in Massachusetts, United States of America. Participants began baseline assessment in 2003 and have participated in three exams in total. The most recent wave of exams ended in 2019.

Study design
Cohort

Number of participants at first data collection

103 (participants)

Age at first data collection

47 - 85 years (participants)

Participant year of birth

Varied (participants)

Participant sex
All

Representative sample at baseline?
No

Sample features

Adults
Older and elderly people
Relatives
Dataset details

Country

United States of America

Year of first data collection

2003

Primary Institutions

Boston University (BU)

Links

framinghamheartstudy.org/participants/participant-cohorts/

Profile paper DOI

doi.org/10.1093/ije/dyv337

Funders

National Heart, Lung, and Blood Institute (NHLBI)

National Institutes of Health (NIH)

Ongoing?
Yes

Data types collected

neuroImagingData
mentalHealthData
dataLinkage
Quantitative data collection
  • Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
  • Interview – face-to-face
  • Interview – phone
  • Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
  • Secondary data
  • Self-report questionnaire – paper or computer assisted
Qualitative data collection
  • None
Neuroimaging data collection
  • Magnetic Resonance Imaging (MRI)
Linked or secondary data
  • Healthcare data
Features

Engagement

  • Participant or community advisory groups
  • Community engagement
  • Keywords

    Alzheimer's disease (AD)
    Biological samples/biospecimens
    Biomarkers
    Cardiovascular health and disease
    Dementia
    Neuroimaging

    Consortia and dataset groups

    Framingham Heart Study
    Global Alzheimer’s Association Interactive Network (GAAIN)
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