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Golestan Cohort Study (GCS)
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Sample details

The GCS evaluates the environmental and genetic risk factors for esophageal squamous cell carcinoma (ESCC) in Golestan Province, Iran. From 2004 to 2008, the study recruited just over 50,000 adults between the ages of 40 to 75 years. All participants have been followed up actively every 12 months. At baseline, out of 50,045 participants, 28,804 of these were women. Three types of outcomes are assessed in the GCS: death (from any cause), occurrence of any cancer (of any site), and occurrence of a UGI cancer (oesophageal or gastric cancer).

Study design
Cohort

Number of participants at first data collection

50,045 (participants)

Age at first data collection

40 - 75 years (participants)

Participant year of birth

Varied (participants)

Participant sex
All

Representative sample at baseline?
No

Sample features

Cancer patients
Patients and clinical populations
Dataset details

Country

Iran

Year of first data collection

2008

Primary Institutions

Golestan University of Medical Sciences (دانشگاه علوم پزشکی و خدمات بهداشتی درمانی گلستان)

International Agency for Research on Cancer (IARC)

National Cancer Institute (NCI) - United States of America

Tehran University of Medical Sciences (دانشگاه علوم پزشکی تهران, TUMS)

Links

dceg.cancer.gov/research/cancer-types/esophagus/golestan-cohort-study-iran-esophageal-squamous-cell-carcinoma

dceg2.cancer.gov/gemshare/studies/GCS/details

Profile paper DOI

doi.org/10.1093/ije/dyp161

Funders

Cancer Research UK (CRUK)

International Agency for Research on Cancer (IARC)

National Cancer Institute (NCI)

National Institutes of Health (NIH)

Tehran University of Medical Sciences (دانشگاه علوم پزشکی تهران, TUMS)

Ongoing?
Yes

Data types collected

dataLinkage
Quantitative data collection
  • Interview – face-to-face
  • Interview – phone
  • Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
  • Secondary data
Qualitative data collection
  • None
Neuroimaging data collection
  • None
Linked or secondary data
  • Healthcare data
Features

Engagement

  • None
  • Keywords

    Anthropometry
    Biological samples/biospecimens
    Cancer
    Cancer registry
    Environmental factors
    Gastrointestinal cancer (e.g. bowel, colon, gastric cancer etc.)
    Genetic factors
    Hospital admissions
    Lifestyle factors
    Morbidity and mortality
    Physical health

    Consortia and dataset groups

    Asia Cohort Consortium (ACC)
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