Genetic Risk and Outcome of Psychosis (GROUP)
GROUP is multi-site longitudinal cohort study investigating genetic and environmental factors contributing to the expression of psychosis in individuals with psychotic disorders, their unaffected family members, and non-related healthy controls. Individuals diagnosed with a non-affective psychotic disorder and aged 16 - 50 years old, were recruited through 36 mental health care institutes across the Netherlands and Belgium. The cohort also comprises siblings and parents of the participants, and a healthy control group of individuals without any first- or second-degree relatives with a psychotic disorder. Participants were assessed at baseline (first wave), 3-year (second wave), and 6-year (third wave) follow-ups.
Study design
Cohort - clinical, Cohort - intergenerational
Number of participants at first data collection
1,057 (siblings)
919 (parents)
590 (controls)
1,120 (participants)
Age at first data collection
16 - 50 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Countries
Year of first data collection
2004
Primary Institutions
Maastricht University (Universiteit Maastricht, UM)
University of Amsterdam (Universiteit van Amsterdam, UvA)
University of Groningen (Rijksuniversiteit Groningen, UG)
Utrecht University (Universiteit Utrecht, UU)
Profile paper DOI
Funders
The Netherlands Organisation for Health Research and Development (ZonMw)
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Interview – face-to-face
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Self-report questionnaire – paper or computer assisted
- None
- None
- Geographic, spatial & environmental data
- Healthcare data
Engagement
Keywords
