The Healthy Mothers, Healthy Communities study was created in 2015 to assess the role of maternal health during pregnancy on infant and child health outcomes in Vanuatu. The collection of data on major life events, perceived stress, anxiety, depression, and health behaviours among pregnant women and to follow their infants’ development from birth to age 2 was originally planned. However, the study was abruptly modified when, in March 2015, the nation was hit by Cyclone Pam, a Category 5 cyclone that left many villages in ruin. Thus, the study was refocused on stress and diet among women exposed to the cyclone during pregnancy and infant development. Objective hardship, distress, and diets following the cyclone and their relationships with infant development were assessed. The total sample included more than 900 women, including 187 women who were pregnant during the cyclone or who became pregnant within the following 3 months. The average age of pregnant women at baseline was 32.9 years, and 25.6 years among women who were not pregnant.