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Hokkaido Study on Environment and Children’s Health
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Sample details

The Hokkaido Study is an ongoing study investigating environmental and genetic influences on health and neurodevelopment from before birth to adulthood. The study consists of two prospective cohorts of mother-child pairs residing in Japan: the Sapporo (Toho hospital) cohort and the Hokkaido (large-scale) cohort. The Sapporo cohort enrolled 514 pregnant women at 23-35 weeks of gestation who planned to deliver at Toho Hospital in Sapporo city between July 2002 and October 2005. The Hokkaido cohort enrolled 20,926 pregnant women before 13 weeks of gestational age who visited one of the associated medical institutions throughout Hokkaido between February 2003 and March 2012.

Study design
Cohort - primary caregiver and child, Cohort - birth

Number of participants at first data collection

514 (Sapporo cohort mother-child pairs)

20,926 (Hokkaido cohort mother-child pairs)

Age at first data collection

Birth (Sapporo cohort children)

Birth (Hokkaido cohort children)

Varied (Sapporo cohort mothers)

Varied (Hokkaido cohort mothers)

Participant year of birth

2002 - 2005 (Sapporo cohort children)

2003 - 2012 (Hokkaido cohort children)

Varied (Sapporo cohort mothers)

Varied (Hokkaido cohort mothers)

Participant sex
All

Representative sample at baseline?
No

Sample features

Newborns, infants and babies
Observational cohort
Pregnant people
Prospective cohort
Two cohorts
Dataset details

Country

Japan

Year of first data collection

2002 (Sapporo cohort mother-child pairs)

2003 (Hokkaido cohort mother-child pairs)

Primary Institutions

Hokkaido University (北海道大学, Hokkaidō daigaku)

Links

cehs.hokudai.ac.jp/hokkaidostudy/

exposome-explorer.iarc.fr/cohorts/103

doi.org/10.1093/ije/dyq071

Funders

Japan Agency for Medical Research and Development (AMED)

Japan Society for the Promotion of Science (JSPS)

Ministry of Education, Culture, Sports, Science and Technology (MEXT/Monbusho)

Ministry of Health, Labor and Welfare (厚生労働省, MHLW)

Ministry of Internal Affairs and Communications

Ongoing?
Yes

Data types collected

neuroImagingData
mentalHealthData
dataLinkage
Quantitative data collection
  • Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
  • Interview – face-to-face
  • Physical environment assessment (e.g. pollution, mould)
  • Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
  • Secondary data
  • Self-report questionnaire – paper or computer assisted
Qualitative data collection
  • None
Neuroimaging data collection
  • Electroencephalography (EEG)
Linked or secondary data
  • Medical birth registry
Features

Engagement

  • Community engagement
  • Keywords

    Allergies
    Autism and Autism-like conditions
    Biological samples/biospecimens
    Chemical exposures
    Environmental exposures
    Epigenetics
    Genetics
    Human development
    Neurodevelopment
    Neurodevelopmental disorders
    Physical health
    Pregnancy outcomes
    Prenatal exposures
    Socioeconomics

    Consortia and dataset groups

    Japan Birth Cohort Consortium (JBiCC)
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