Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM)
The HOPE-SAM study is a longitudinal observational cohort that aims to evaluate the short- and long-term clinical outcomes of human immunodeficiency virus (HIV)-positive and HIV-negative children with complicated severe acute malnutrition (SAM). Children aged between 0 and 59 months hospitalised for SAM were enrolled at three tertiary hospitals in Harare, Zimbabwe, and Lusaka, Zambia. Longitudinal mortality, morbidity, and nutritional data were collected at admission, discharge, and for 48 weeks post discharge. Nested laboratory substudies are exploring the role of enteropathy, gut microbiota, metabolomics, and cellular immune function in the pathogenesis of SAM using stool, urine, and blood collected from participants and from well-nourished controls.
Study design
Cohort
Number of participants at first data collection
745 (participants)
Age at first data collection
0 - 4.9 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Countries
Year of first data collection
2016
Primary Institutions
Medical Research Council of Zimbabwe
Queen Mary University of London (QMUL)
University of Zambia (UNZA)
Profile paper DOI
Funders
Medical Research Council (MRC)
Queen Mary University of London
Wellcome Trust
Ongoing?
Yes
Data types collected
- Activity log (e.g. food, sleep, exercise)
- Interview – face-to-face
- Interview – phone
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- None
- None
Engagement
Keywords
