Human Trisome Project (HTP)
The HTP study is a United States of America-based longitudinal cohort study designed to comprehensively investigate the biology of Down syndrome by integrating biospecimens, multi-omics, and detailed clinical data. Since 2016, 1,290 individuals have been recruited. Participants include those with Down syndrome, their family members and matched euploid controls, ranging in age from 6 months to 89 years. Recruitment has been conducted through clinical partnerships and community outreach led by the Linda Crnic Institute for Down Syndrome at the University of Colorado. Participants are followed at multiple time points over several years, with follow-up frequency varying by study aims and individual availability.
Study design
Biobank, Cohort, Cohort - clinical
Number of participants at first data collection
1,290 (participants as of 2018)
Recruitment is ongoing
Age at first data collection
6 months - 89 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2016
Primary Institutions
University of Colorado Anschutz Medical Campus (Academic, United States of America)
Profile paper DOI
Not available
Funders
Anna and John J. Sie Foundation (Third Sector, United States of America)
Global Down Syndrome Foundation (Research, United States of America)
University of Colorado Boulder (CU Boulder) (Academic, United States of America)
Ongoing?
Yes
Data types collected
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Secondary data
- Self-completed questionnaire – paper or computer assisted
- None
- None
- Healthcare data
Engagement
Keywords
Consortia and dataset groups
