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Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure study (INSPIRE)
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Sample details

INSPIRE is a population based longitudinal birth cohort of over 1,900 term healthy infants, recruited from either paediatric practices in Middle Tennessee, United States of America, or self-referral through research announcements. Infants who were enrolled in the study had their birthdays within 2 periods spanning from the beginning of June to the end of December in 2012 and 2013, so that infants were on average younger than 6 months of age during winter virus season, when RSV infection is likely to both represent the first and most severe infection.

Study design
Cohort - birth

Number of participants at first data collection

1,952 (participants)

Age at first data collection

Birth (participants)

Participant year of birth

2012 - 2013 (participants)

Participant sex
All

Representative sample at baseline?
No

Sample features

Newborns, infants and babies
Population-based sample
Respiratory illness
Dataset details

Country

United States of America

Year of first data collection

2012

Primary Institutions

Vanderbilt University Medical Center (VUMC)

Links

doi.org/10.1016/S0140-6736(23)00811-5

Funders

National Heart, Lung, and Blood Institute (NHLBI)

National Institute of Allergy and Infectious Diseases (NIAID)

Vanderblit University Medical Center (VUMC)

Ongoing?
Yes

Data types collected

Quantitative data collection
  • Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
  • Self-report questionnaire – online
Qualitative data collection
  • None
Neuroimaging data collection
  • None
Linked or secondary data
  • None
Features

Engagement

  • Patients, service users, lived experience involvement
  • Keywords

    Asthma
    Biological samples/biospecimens
    Epidemiology
    Infant biosamples
    Infant health
    Population-based
    Respiratory health and disease
    Sub-studies

    Consortia and dataset groups

    Children’s Respiratory and Environmental Workgroup (CREW)
    Environmental influences on Child Health Outcomes (ECHO)
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