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Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure study (INSPIRE)
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Sample details

INSPIRE is a population based longitudinal birth cohort of over 1,900 term healthy infants, recruited from either paediatric practices in Middle Tennessee, United States of America, or self-referral through research announcements. Infants who were enrolled in the study had their birthdays within 2 periods spanning from the beginning of June to the end of December in 2012 and 2013, so that infants were on average younger than 6 months of age during winter virus season, when RSV infection is likely to both represent the first and most severe infection.

Study design
Cohort - birth

Number of participants at first data collection

1,952 (participants)

Age at first data collection

Birth (participants)

Participant year of birth

2012 - 2013 (participants)

Participant sex
All

Representative sample at baseline?
No

Sample features

Newborns, infants and babies
Population-based sample
Respiratory illness
Dataset details

Country

United States of America

Year of first data collection

2012

Primary Institutions

Vanderbilt University Medical Center (VUMC) (Research, United States of America)

Links

doi.org/10.1016/S0140-6736(23)00811-5

Funders

National Heart, Lung, and Blood Institute (NHLBI) (Government, United States of America)

National Institute of Allergy and Infectious Diseases (NIAID) (Government, United States of America)

Vanderblit University Medical Center (VUMC) (Healthcare/Medical, United States of America)

Ongoing?
Yes

Data types collected

Quantitative data collection
  • Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
  • Self-completed questionnaire – online
Qualitative data collection
  • None
Neuroimaging data collection
  • None
Linked or secondary data
  • None
Features

Engagement

  • Patients, service users, lived experience involvement
  • Keywords

    Asthma
    Biological samples/biospecimens
    Epidemiology
    Infant biosamples
    Infant health
    Population-based
    Respiratory health and disease
    Sub-studies

    Consortia and dataset groups

    Children’s Respiratory and Environmental Workgroup (CREW)
    Environmental influences on Child Health Outcomes (ECHO)
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