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Life-style factors on the Development of the Immune System and Allergies in East and West Germany (LISA)
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Sample details

LISA investigates how lifestyle factors affect immune system development and allergies in children in Germany. Participants were recruited from maternity wards in Munich, Leipzig, Wesel, and Bad Honnef between November 1997 and January 1999. At baseline, over 3,000 infants were included in the cohort. Participants have been followed up at specific intervals: 0.5, 1, 1.5, 2, 4, 6, 10, 15, 20, and 25 years of age.

Study design
Cohort - birth

Number of participants at first data collection

3,097 (participants)

Age at first data collection

Birth (participants)

Participant year of birth

1997 - 1999 (participants)

Participant sex
All

Representative sample at baseline?
No

Sample features

Adolescents
Children and young people
Newborns, infants and babies
Young adults
Dataset details

Country

Germany

Year of first data collection

1997

Primary Institutions

Evangelical Hospital Düsseldorf (Evangelisches Krankenhaus Düsseldorf)

Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

Leibniz Research Institute for Environmental Medicine (Leibniz-Institut für umwelt­medizinische Forschung, IUF)

Marien-Hospital Wesel

University of Leipzig (Universität Leipzig)

Links

helmholtz-munich.de/en/epi/cohort/lisa

lisastudie.de/

mica.mdc-berlin.de/study/lisa

Funders

European Union (EU)

Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF) now known as Federal Ministry of Research, Technology and Space (Bundesministerium für Forschung, Technologie und Raumfahrt, BMFTR)

Helmholtz Association (Helmholtz-Gemeinschaft Deutscher Forschungszentren)

Leibniz Research Institute for Environmental Medicine (Leibniz-Institut für umwelt­medizinische Forschung, IUF)

Ongoing?
Yes

Data types collected

dataLinkage
Quantitative data collection
  • Activity log (e.g. food, sleep, exercise)
  • Interview – face-to-face
  • Physical environment assessment (e.g. pollution, mould)
  • Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
  • Self-report questionnaire – unspecified
Qualitative data collection
  • None
Neuroimaging data collection
  • None
Linked or secondary data
  • Geographic, spatial & environmental data
Features

Engagement

  • Community engagement
  • Keywords

    Allergies
    Biological samples/biospecimens
    COVID-19
    Diet and nutrition
    Genetics
    Human development
    Immunity
    Intrauterine exposures
    Metabolomics
    Microbiome
    Pollution

    Consortia and dataset groups

    European Study of Cohorts for Air Pollution Effects (ESCAPE)
    Intestinal Microbiomics Knowledge Platform (INTIMIC-KP)
    Traffic-Related Air Pollution and Childhood Asthma (TRAPCA)
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