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LifeLines
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Sample details

Lifelines is a large population-based cohort study and biobank that includes over 167,000 participants from the northern population of the Netherlands, with the aim to follow up for at least 30 years. Between 2006 and 2013, participants aged 0 to 93 years were enrolled using a three-generation recruitment design. At baseline, the cohort was 58% female, and the mean age was 41 years. Participants are followed up every 1.5-2.5 years with questionnaires, and every 5 years with physical examinations and biosample collection.

Study design
Cohort - intergenerational, Biobank

Number of participants at first data collection

167,729 (participants)

Recruitment is ongoing

Age at first data collection

6 months - 93 years (participants)

Participant year of birth

Varied (participants)

Participant sex
All

Representative sample at baseline?
The adult population of the north of the Netherlands

Sample features

Intergenerational
Population-based sample
Dataset details

Country

Netherlands

Year of first data collection

2006

Primary Institutions

University Medical Center Groningen (Universitair Medisch Centrum Groningen, UMCG)

University of Groningen (Rijksuniversiteit Groningen, UG)

Links

lifelines-biobank.com/

maelstrom-research.org/study/lifelines

doi.org/10.1093/ije/dyu229

Profile paper DOI

doi.org/10.1093/ije/dyab257

Funders

Dutch Research Council (Nederlandse Organisatie voor Wetenschappelijk Onderzoek, NWO)

European Regional Development Fund (ERDF)

Ministry of Economic Affairs (Ministerie van Economische Zaken, EZ)

Ministry of Health, Labor and Welfare (厚生労働省, MHLW)

Northern Netherlands Alliance (Samenwerkingsverband Noord-Nederland, SNN)

Ongoing?
Yes

Data types collected

neuroImagingData
mentalHealthData
dataLinkage
Quantitative data collection
  • Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
  • Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
  • Secondary data
  • Self-report questionnaire – unspecified
Qualitative data collection
  • None
Neuroimaging data collection
  • Magnetic Resonance Imaging (MRI)
Linked or secondary data
  • Census data
  • Geographic, spatial & environmental data
  • Healthcare data
  • Medical birth registry
  • Mortality data
Features

Engagement

  • None
  • Keywords

    Biological samples/biospecimens
    Cognitive assessments
    Diet and nutrition
    Environmental exposures
    Genomics
    Health and wellbeing
    Healthcare access and use
    Lifestyle
    Mental health
    Microbiome
    Personality
    Physical health assessments
    Psychosocial factors

    Consortia and dataset groups

    Cross-cohort Harmonization Project for Tomorrow (CHPT)
    Geoscience and health cohort consortium (GECCO)
    LifeLines
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