Leiden Longevity Study (LLS)
The aim of the LLS is to uncover genetically determined mechanisms of longevity and to investigate their interaction with the environment. Baseline data collection and recruitment took place from 2002 to 2006 when 420 families including over 940 siblings aged at least 89 years old were recruited via municipal registries in the Netherlands. During the same period, around 1,700 offspring of these participants were also recruited, along with around 740 of their partners. Participants have been followed up several times over the following years, including mortality and active follow up visits for some sub-cohorts. The most recent follow up of the offspring cohort took place from 2021 to 2023.
Study design
Cohort, Cohort - intergenerational
Number of participants at first data collection
944 (long-lived siblings)
1,671 (offspring cohort)
744 (partners of offspring cohort)
Age at first data collection
≥ 89 years (long-lived siblings)
Varied (offspring cohort)
Varied (partners of offspring cohort)
Participant year of birth
Varied (long-lived siblings)
Varied (offspring cohort)
Varied (partners of offspring cohort)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2002
Primary Institutions
Leiden University (Universiteit Leiden, LEI)
Leiden University Medical Center (Leids Universitair Medisch Centrum, LUMC)
Profile paper DOI
Funders
Centre for Medical Systems Biology (CMSB)
Dutch Research Council (NWO, Nederlandse Organisatie voor Wetenschappelijk Onderzoek)
European Union (EU)
Government of the Netherlands (Rijksoverheid)
Netherlands Genomics Initiative (NGI)
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Interview – face-to-face
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Secondary data
- None
- None
- Census data
- Healthcare data
- Mortality data
- Other government data
Engagement
Keywords
