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Longitudinal MRI Study of Hippocampal Volume in Trauma Survivors With PTSD
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Sample details

The cohort of the current study includes 44 adult survivors of traumatic events who were assessed for post-traumatic stress within a week of the traumatic event and again 6 months later. The assessment included an MRI of the brain, psychometric testing, and structured clinical interviews. Thirty-nine (89%) of 44 consenting subjects completed the study, and 37 (95%) of those had valid MRI scans at both time points. During the traumatic event, participants in this study did not suffer a head injury or a physical injury necessitating hospital admission or major surgery. In addition, no subjects had a lifetime history of neurological disorder, psychotic disorder, PTSD, or substance abuse. The resulting PTSD and non-PTSD participants had similar mean ages (33.7 and 29.8 years, respectively), and similar mean education levels (13.4 and 12.4 years in school, respectively).

Study design
Cohort - clinical

Number of participants at first data collection

44 (participants)

Age at first data collection

Varied (participants)

Participant year of birth

Varied (participants)

Participant sex
All

Representative sample at baseline?
No

Sample features

Patients and clinical populations
Trauma survivors
Dataset details

Country

Israel

Year of first data collection

1999

Primary Institutions

Brigham and Women’s Hospital (BWH)

Hadassah University Hospital

Harvard Medical School (HMS)

Links
No website available

Profile paper DOI

doi.org/10.1176/appi.ajp.158.8.1248

Funders

National Institute of Mental Health (NIMH)

Ongoing?
No

Data types collected

neuroImagingData
mentalHealthData
Quantitative data collection
  • Interview – face-to-face
Qualitative data collection
  • None
Neuroimaging data collection
  • Magnetic Resonance Imaging (MRI)
Linked or secondary data
  • None
Features

Engagement

  • None
  • Keywords

    Brain functioning
    Hippocampal functions
    Magnetic Resonance Imaging (MRI)
    Neuroimaging
    Post-traumatic stress disorder (PTSD)
    Trauma
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