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Markers of Autism Risk in Babies - Learning Early Signs (MARBLES)
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Sample details

The MARBLES study investigates possible prenatal and post-partum biological and environmental exposures and risk factors that may contribute to the development of autism spectrum disorder (ASD). Women who already have a child diagnosed with an ASD and who are pregnant or planning an additional pregnancy have been recruited for the study, primarily through the California Department of Developmental Services in the United States of America. Over 500 pregnant women have been enrolled in the study. The study, which began baseline assessment in 2006, follows women from early in their pregnancy to when the child is 36 months of age. This includes weekly diaries, home visits and monthly assessments of the mother, child and sibling.

Study design
Cohort, Cohort - birth, Cohort - primary caregiver and child

Number of participants at first data collection

522 (families)

Recruitment is ongoing

Age at first data collection

Varied (mothers)

Birth (children)

Varied (siblings)

Participant year of birth

Varied (mothers)

Varied (children)

Varied (siblings)

Participant sex
All

Representative sample at baseline?
No

Sample features

Autism Spectrum Disorder (ASD)
Mothers
Parents of children with autism
Pregnant people
Siblings
Dataset details

Country

United States of America

Year of first data collection

2006

Primary Institutions

University of California, Davis (UC Davis)

Links

marbles.ucdavis.edu/

health.ucdavis.edu/mindinstitute/research/marbles/

studypages.com/s/marbles-markers-of-autism-risk-in-babies-learning-early-signs-783484/

doi.org/10.1016/j.envres.2025.121646

clinicaltrials.gov/study/NCT03468959

reporter.nih.gov/project-details/10980425

niehs.nih.gov/research/supported/epidemiology/maintaining-cohorts/grantees/marbles

tools.niehs.nih.gov/cohorts/index.cfm/main/detail/ids/c71

Profile paper DOI

doi.org/10.1289/EHP535

Funders

National Institute of Environmental Health Sciences (NIEHS)

National Institutes of Health (NIH)

United States Environmental Protection Agency (EPA)

University of California, Davis (UC Davis)

Ongoing?
Yes

Data types collected

mentalHealthData
Quantitative data collection
  • Activity log (e.g. food, sleep, exercise)
  • Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
  • Interview – face-to-face
  • Physical environment assessment (e.g. pollution, mould)
  • Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
Qualitative data collection
  • None
Neuroimaging data collection
  • None
Linked or secondary data
  • None
Features

Engagement

  • Community engagement
  • Keywords

    Autism and Autism-like conditions
    Biological samples/biospecimens
    Biomarkers
    Chemical exposures
    Environment
    Environmental exposures
    Human development
    Infant biosamples
    Maternal health

    Consortia and dataset groups

    Environmental influences on Child Health Outcomes (ECHO)
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