Mood and Resilience in Offspring (MARIO)
MARIO is an observational, longitudinal cohort study in offspring of parents with a mood disorder and offspring of controls, aged between 10 and 25 years in the Netherlands. Offspring were recruited from existing patient studies. During this 3-year longitudinal study, data are collected at 4 time points (baseline (T0), 1 year (T1), 2 years (T2), and 3 years (T3) after baseline). Over this period of three years, extensive clinical, biological, and environmental data and data on risk and resilience are collected through various methods, including blood sampling, face-to-face interviews, online questionnaires, actigraphy, and experience sampling method assessment.
Study design
Cohort
Number of participants at first data collection
~450 (participants)
~100 (controls)
Recruitment is ongoing
Age at first data collection
10 - 25 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2020
Primary Institutions
Erasmus University Medical Centre (Erasmus MC)
Leiden University Medical Center (Leids Universitair Medisch Centrum, LUMC)
University Medical Center Groningen (Universitair Medisch Centrum Groningen, UMCG)
University Medical Center Utrecht (Universitair Medisch Centrum Utrecht, UMCU)
VU University Medical Center (VU Medisch Centrum, VUmc)
Profile paper DOI
Funders
The Netherlands Organisation for Health Research and Development (ZonMW)
Ongoing?
Yes
Data types collected
- Activity log (e.g. food, sleep, exercise)
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Interview – face-to-face
- Interview – phone
- Passive electronic data collection (e.g. screen time, scroll speed)
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Secondary data
- Self-report questionnaire – online
- Self-report questionnaire – paper or computer assisted
- Wearable devices
- None
- None
- Existing research data
Engagement
Keywords
Consortia and dataset groups
