In 1999, the two cohorts of the Swiss Neonatal HIV Study and the Swiss HIV and Pregnancy Study were combined to form the MoCHiV mother and child cohort. MoCHiV investigates measures to prevent mother-to-child transmission in pregnant women with human immunodeficiency virus (HIV) and assesses the health and development of their exposed children, as well as of children with HIV (CWH) in general in Switzerland. Between 1986 and 2022, a total of 1446 mother-child dyads were enrolled, as well as 187 CWH and 521 HIV-exposed but uninfected children (HEU). In 2003, MoCHiV was integrated into the Swiss HIV Cohort Study (SHCS). Pregnant women with HIV are followed semiannually according to the SHCS protocol, as well as supplementary follow-ups during pregnancy. All infants are assessed at 1, 2, 6, and 18 to 24 months of age. Following this, CWH are examined every 6 months, and HEU are followed every 6 months until 1 year of age, and then annually until 5 years of age. CWH are offered to be transferred to the SHCS at the age of 18 years.

Recruitment is ongoing