Multilevel Biomarkers for Suicidal Behavior: From Interpersonal Stress to Gene Expression in a Longitudinal Study of Adolescent Girls
The study aimed to investigate the biological and behavioural responses to stress and risk for internalising symptoms and self-injurious thoughts and behaviours in adolescent girls in the United States of America. Participants were approximately 230 adolescents assigned female at birth, aged 9 to 14 years, who endorsed experiencing at least one mental health concern (e.g., depression, anxiety) in the two years before study recruitment. Baseline data collection began in 2015, and follow-up occurred in multiple waves over one year. A subset of participants participated in MRI scans.
Study design
Cohort
Number of participants at first data collection
229 (participants)
Age at first data collection
9 - 15 years (participants)
Participant year of birth
Varied (participants)
Participant sex
Female
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2015
Primary Institutions
University of North Carolina at Chapel Hill (UNC)
Profile paper DOI
Funders
National Institute of Mental Health (NIMH)
National Institutes of Health (NIH)
Ongoing?
No
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Interview – face-to-face
- Interview – phone
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Functional magnetic resonance imaging (fMRI)
- None
Engagement
Keywords
