North American Prodrome Longitudinal Study-3 (NAPLS-3)
The NAPLS is a consortium of nine programs. NAPLS-3 is the third phase of the project and a five-year prospective study, involving 710 clinically high-risk participants aged 12 to 30 years, meeting the Criteria of Psychosis-Risk Syndromes (COPS). Recruitment spanned three years (February 2015 to November 2018), with two years of follow-up assessments. Clinical and biomarker assessments occurred every two months for the first 8 months, followed by clinical assessments at 12, 18, and 24 months. For those transitioning to psychosis, assessments were repeated at transition and one year post-transition to confirm diagnosis.
Study design
Cohort - clinical
Number of participants at first data collection
710 (participants)
Age at first data collection
12 - 30 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2015
Primary Institutions
Emory University
Harvard University
University of Calgary
University of California, Los Angeles (UCLA)
University of California, San Diego (UC San Diego)
Profile paper DOI
Funders
National Institute of Mental Health (NIMH)
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Electroencephalography (EEG)
- Functional magnetic resonance imaging (fMRI)
- Magnetic Resonance Imaging (MRI)
- None
Engagement
Keywords
Consortia and dataset groups
