North American Prodrome Longitudinal Study 2 (NAPLS2)
The NAPLS is a consortium of nine programs. NAPLS2 was the second phase of the project, a five-year prospective study involving 764 clinically high-risk participants aged 12 to 35 years who met the Criteria of Psychosis-Risk Syndromes (COPS). Between January 2009 and January 2012, the study recruited participants aged 12 to 35 years from eight sites across the United States of America. Recruited CHR participants met the criteria for a prodromal syndrome or schizotypal personality disorder (SPD). Recruited control participants did not meet the diagnostic criteria for any prodromal syndrome, psychotic disorder or cluster A personality disorder and had no family history of any psychotic disorder or symptoms. All participants were followed up on every six months for a period of two years.
Study design
Cohort, Cohort - clinical
Number of participants at first data collection
764 (CHR participants)
280 (control participants)
Age at first data collection
12 - 35 years (CHR participants)
12 - 35 years (control participants)
Participant year of birth
Varied (CHR participants)
Varied (control participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Countries
Year of first data collection
2009
Primary Institutions
Emory University
Harvard University
University of Calgary
University of California, Los Angeles (UCLA)
University of California, San Diego (UC San Diego)
Profile paper DOI
Funders
Commonwealth of Massachusetts
National Institute of Mental Health (NIMH)
Ongoing?
No
Data types collected
- Interview – face-to-face
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Electroencephalography (EEG)
- Functional magnetic resonance imaging (fMRI)
- None
Engagement
Keywords
Consortia and dataset groups
