Neuroprogression across the Psychosis Spectrum in the Early Course of Illness
This study is an extension of the Human Connectome Project for Early Psychosis and aimed to categorise neuroprogression throughout the early course of psychosis and to understand the association of neuroprogressive trajectories with clinical and functional outcomes. From 2019, the study recruited approximately 130 patients with schizophrenia‐spectrum disorders or mood disorders with psychotic features, aged 18 to 35 years, from hospitals in Massachusetts, United States of America. Assessments were conducted at baseline, 8- and 16-month follow-ups.
Study design
Cohort, Cohort - clinical
Number of participants at first data collection
127 (participants)
Age at first data collection
18 - 35 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2019
Primary Institutions
McLean Hospital
Profile paper DOI
Funders
National Institute of Mental Health (NIMH)
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Interview – face-to-face
- Secondary data
- Self-report questionnaire – paper or computer assisted
- None
- Functional magnetic resonance imaging (fMRI)
- Magnetic Resonance Imaging (MRI)
- Healthcare data
Engagement
Keywords
Consortia and dataset groups
