Oxford Risk Factors And Non-invasive Imaging Study (ORFAN)
The ORFAN study aimed to evaluate the risk profile and event rates among patients undergoing coronary computed tomography angiography (CCTA) as part of routine clinical care in the United Kingdom's National Health Service (NHS). This multi-centre, longitudinal cohort study included over 40,000 consecutive patients undergoing clinically indicated CCTA in eight hospitals, who were followed up for major adverse cardiac events for a median of 2.7 years. The study also included a nested cohort of over 3,300 consecutive patients from two ORFAN sites, who were followed up for a median of 7.7 years.
Study design
Cohort - clinical
Number of participants at first data collection
43,484 (participants)
Age at first data collection
18 - 99 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Countries
Year of first data collection
2010 (ORFAN data)
2005 (linkage data)
Primary Institutions
University of Oxford
Links
Profile paper DOI
Funders
National Consortium for Intelligent Medical Imaging
British Heart Foundation
European Commission
Innovate UK (UKRI)
National Health Service (NHS)
Ongoing?
Yes
Data types collected
- Interview – phone
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Secondary data
- None
- Computerized tomography (CT)
- Census data
- Healthcare data
- Mortality data
- Social care data
Engagement
Keywords
