The PISCIS Cohort is a prospective, open, population-based, longitudinal cohort study of people living with human immunodeficiency virus (HIV; PLWH) in Catalonia and the Balearic Islands in Spain, active since 1998 and with a coverage of HIV-diagnosed patients of 82% and 60%, respectively. As of December 2020, over 28,000 PLWH were enrolled in the cohort (273,488 person-years of follow-up). The cohort is largely male (80.9%), the main route of HIV transmission was through sex between men (43.9%), and migrants (non-Spanish origin) contribute 28.8% of patients. Out of all PLWH, 7,020 (25.1%) had AIDS at cohort inclusion and 5,961 (21.3%) developed AIDS during follow-up. Data are solicited from 17 participating centres annually. Patients’ visits are between every 6 and 12 months. Sociodemographic, clinical, laboratory, and antiretroviral treatment (ART) data are collected longitudinally, and treatment prescriptions are extracted from the Catalan Healthcare System database.

Recruitment is ongoing