Preterm behavioral phenotype: trajectories of psychopathology & changes in cerebral connectivity
This study was designed to understand the changes in brain structure and function that underlie the elevated rates of inattention, anxiety and autism spectrum symptoms. From 2007, the study recruited 137 very preterm participants (23 to 30 weeks of gestational age) and 165 full-term participants (37 to 41 weeks of gestational age) with high rates of psychosocial adversity. Participants have been followed since birth, with data obtained from medical records at birth, and assessments at ages 2, 5, and 9-10 years. The study plans an additional follow-up at age 14-15 years.
Study design
Cohort, Cohort - birth
Number of participants at first data collection
137 (very preterm participants)
165 (full-term participants)
Age at first data collection
Birth (very preterm participants)
Birth (full-term participants)
Participant year of birth
Varied (very preterm participants)
Varied (full-term participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2009
2007 (birth records)
Primary Institutions
Washington University in St. Louis (WashU)
Profile paper DOI
Funders
Brain and Behavior Research Foundation (BBRF)
Cerebral Palsy International Research Foundation
Child Neurology Foundation
Dana Foundation
Doris Duke Foundation (DDF)
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Interview – unspecified
- Secondary data
- Self-report questionnaire – unspecified
- None
- Functional magnetic resonance imaging (fMRI)
- Magnetic Resonance Imaging (MRI)
- Healthcare data
- Medical birth registry
Engagement
Keywords
