Prenatal Identification of Children's Health (PRINCE)
The PRINCE study is a longitudinal pregnancy open cohort based in Hamburg, Germany, comprising 664 pregnant women and their offspring. It aims to investigate how maternal antibody levels and placental function influence neonatal immunity and susceptibility to early-life infections. Participants were recruited through resident gynaecologists during routine antenatal care visits, beginning in 2011. The cohort includes women aged 18 years and older with viable singleton pregnancies at 12-14 weeks of gestation. A subset of 141 mother-neonate pairs from the full cohort was used for specific immunological analyses. Assessments were conducted three times during pregnancy, specifically at 12-14 weeks, 20-22 weeks, and 30-32 weeks of gestation, with additional data collected at birth and during the first six months of the infant’s life.
Study design
Cohort, Cohort - open
Number of participants at first data collection
664 (mothers)
664 (children)
Recruitment is ongoing
Age at first data collection
≥ 18 years (mothers)
Birth (children)
Participant year of birth
Varied (mothers)
Varied (children)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2011
Primary Institutions
Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
University Medical Center Hamburg-Eppendorf (Universitätsklinikum Hamburg-Eppendorf, UKE)
Profile paper DOI
Funders
German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)
Ongoing?
Yes
Data types collected
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Self-report questionnaire – paper or computer assisted
- None
- None
- None
Engagement
Keywords
