Risk Assessment of Cnm-Positive Streptococcus mutans in Stroke Survivors (RAMESSES)
RAMESSES, initiated in November 2018, is a 2-year multicenter, prospective cohort study exploring the effect of Cnm-positive Streptococcus mutans (S. mutans) in the oral cavity on the risk of cerebral microbleeds (CMBs) development and cognitive decline. The study involves 15 institutes, including the National Cerebral and Cardiovascular Center (NCVC) as the central coordinating center, located in Japan. The study includes 230 patients who developed stroke within 1 year after onset and were diagnosed with at least one hemorrhagic lesion involving CMBs or ICH in the deep area. The outcomes have been assessed at baseline, 6, 12, 18, and 24 months.
Study design
Cohort - clinical
Number of participants at first data collection
230 (participants)
Age at first data collection
≥ 40 years (participants)
Participant year of birth
Varied (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2018
Primary Institutions
National Research and Development Agencies (国立研究開発法人)
Links
Profile paper DOI
Funders
Bristol-Myers Squibb (BMS)
Grant-in-Aid for Early-Career Scientists (KAKENHI)
Pfizer
Ongoing?
Yes
Data types collected
- Computer, paper or task testing (e.g. cognitive testing, theory of mind doll task, attention computer tasks)
- Interview – face-to-face
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- None
- Magnetic Resonance Imaging (MRI)
- None
Engagement
Keywords
Consortia and dataset groups
