The National Institute of Mental Health (NIMH) launched the RDoC project in 2013 to create a framework for research on pathophysiology, especially for genomics and neuroscience, which ultimately will inform future classification schemes. The sample consists of individuals who presented to the University of California, San Diego (UCSD) and the University of California, Los Angeles (UCLA) primary care clinics, both in the United States. Participants of the project were aged between 18 and 55 years at baseline, and scored above threshold for anxiety and/or depression symptoms using various standard assessments. All participants were then followed up 3 months after baseline to complete the screening assessments for a second time.