The SABPA study is a South African prospective cohort study investigating how chronic stress and sympathetic nervous system activity contribute to cardiometabolic disease. Between 2008 and 2009, 409 urban-dwelling Black and White African teachers from 43 schools in the North-West Province were recruited and underwent baseline assessments (Phase 1). Participants were well-educated adults with medical aid benefits. Follow-up assessments were conducted between 2011 and 2012, approximately three years later (Phase 2). The study is also planning a third phase.