The SCS aims to shed light on the determinants of successful ageing, both environmental and genetic. Participants include residents of Sydney, Australia, aged 95 years and above. Participants are interviewed at baseline, 6 months, 12 months, 18 months, and at every subsequent 12-month interval. To date, 410 participants aged 95 and above are included and are from the East, Inner West, and Inner South of Sydney. Seventy-one percent of the participants are female, with the mean age at baseline being 97.4 years (age range at baseline was 95.02-106.3 years). Twenty-six percent of participants are from a non-English-speaking background; 39% of participants were living in aged care, with 60% of those in aged care living in high-care accommodation.