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Sister Study
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Sample details

The Sister Study is a prospective study of environmental and genetic risk factors for breast cancer and other health outcomes among a cohort of over 50,000 sisters of women who have had breast cancer. The cohort consists of women aged 35-74 without a history of breast cancer at baseline who were recruited from 2003 to 2009 from all 50 states across the United States of America and Puerto Rico. The women are followed up for at least 10 years with health updates each year, as well as detailed questionnaires about health, lifestyles, and environmental exposures every two to three years.

Study design
Cohort

Number of participants at first data collection

50,884 (participants)

Age at first data collection

35 - 74 years (participants)

Participant year of birth

Varied (participants)

Participant sex
Female

Representative sample at baseline?
No

Sample features

Adults
Women
Dataset details
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Countries

Puerto Rico, United States of America

Year of first data collection

2003

Primary Institutions

National Institute of Environmental Health Sciences (NIEHS)

Links

sisterstudy.niehs.nih.gov/English/index1.htm

sisterstudy.niehs.nih.gov/English/researchers.htm

Profile paper DOI

doi.org/10.1289/EHP1923

Funders

National Institute of Environmental Health Sciences (NIEHS)

National Institute on Minority Health and Health Disparities (NIMHD)

Ongoing?
Yes

Data types collected

mentalHealthData
qualitativeData
dataLinkage
Quantitative data collection
  • Interview – phone
  • Physical environment assessment (e.g. pollution, mould)
  • Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
  • Self-report questionnaire – online
  • Self-report questionnaire – paper or computer assisted
Qualitative data collection
  • Interviews or focus groups
Neuroimaging data collection
  • None
Linked or secondary data
  • Geographic, spatial & environmental data
  • Healthcare data
  • Mortality data
Features

Engagement

  • Community engagement
  • Keywords

    Biological samples/biospecimens
    Breast cancer
    Environmental exposures
    Environmental factors
    Health behaviour
    Lifestyle factors
    Occupational exposure
    Physical health assessments
    Stress
    Sub-studies
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