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Stress, Pregnancy, and Health Study (SPAH Study)
Stress, Pregnancy, and Health Study logo
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Sample details

The SPAH study aimed to identify biological mechanisms during pregnancy that contribute to physical and mental health problems. Over 600 pregnant women in Chicago, Illinois, United States of America, were recruited from 2018 to 2022. Participants attended in-person data collection visits in their second and third trimesters of pregnancy, and following delivery, placentas were collected, and data were collected from electronic medical records. The children of participants are being followed up through the SPAH Kids study.

Study design
Cohort

Number of participants at first data collection

605 (participants)

Age at first data collection

≥ 18 years (participants)

Participant year of birth

Varied (participants)

Participant sex
Female

Representative sample at baseline?
No

Sample features

Pregnant people
Women
Dataset details

Country

United States of America

Year of first data collection

2018

Primary Institutions

NorthShore University HealthSystem

Northwestern University (NU)

Links

sites.northwestern.edu/spah/

foundationsofhealth.org/research/spah/

doi.org/10.3389/fgwh.2025.1540376

doi.org/10.1002/pmf2.70026

reporter.nih.gov/search/gWAAlZQjCUWUcEfOY8Xdcw/project-details/10151477

Profile paper DOI
Not available

Funders

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

National Institute on Minority Health and Health Disparities (NIMHD)

National Institutes of Health (NIH)

Ongoing?
No

Data types collected

mentalHealthData
qualitativeData
dataLinkage
Quantitative data collection
  • Interview – face-to-face
  • Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
  • Secondary data
  • Self-report questionnaire – paper or computer assisted
Qualitative data collection
  • Interviews or focus groups
Neuroimaging data collection
  • None
Linked or secondary data
  • Healthcare data
  • Medical birth registry
Features

Engagement

  • None
  • Keywords

    Biological determinants
    Biological samples/biospecimens
    Birth records and measurement
    Health and wellbeing
    Mixed methods
    Pregnancy
    Prenatal exposures
    Prenatal risk factors
    Risk factors
    Stress

    Consortia and dataset groups

    Stress Pregnancy and Health (SPAH)
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