The Speedwell Study was set up in 1979 by the Avon Health Authority to determine risk factors for ischaemic heart disease. Participants were all men aged 45 – 63 that were registered with 16 general practitioners in 2 health centres in the Speedwell neighbourhood of Bristol, United Kingdom, in 1979. At phase 1 (1972–1982) 2,348 participants were recruited and underwent a clinical examination and completed a questionnaire. Participants were re-examined at 4 subsequent follow-ups (phase 2: 1982–1985, phase 3: 1985–1988, phase 4:1988–1991; phase 5: 1997–1999).