Study of Asthma, Genes and the Environment (SAGE)
SAGE is a birth cohort and nested case-control study investigating the origins of asthma and other atopic diseases in a cohort of children born in Manitoba, Canada in 1995. The cohort included 13,980 children followed-up using longitudinal healthcare records from birth until age 7 to 8 years. From a mail-out survey of all households in the SAGE birth cohort, a subsample were selected for the nested case-control study at age 7 to 10 years comprising 246 children with asthma and/or allergies, and 477 children without either. For the control sample, children from rural, low-income areas, and First Nation communities were oversampled to ensure representation from diverse environmental exposures. Participants in the case-control study were assessed again at age 11 to 14 years.
Study design
Cohort - birth, Registry, Cohort
Number of participants at first data collection
13,980 (participants)
Age at first data collection
7 - 8 years (participants)
Participant year of birth
1995 (participants)
Participant sex
All
Representative sample at baseline?
No
Sample features
Country
Year of first data collection
2002
1995 (Linked data)
Primary Institutions
University of Manitoba (UManitoba)
Links
sagenet-sage.blogspot.com/p/frequently-asked-questions.html
Profile paper DOI
Funders
Canadian Institutes of Health Research (CIHR, Instituts de recherche en santé du Canada, IRSC)
Ongoing?
No
Data types collected
- Physical environment assessment (e.g. pollution, mould)
- Physical or biological assessment (e.g. blood, saliva, gait, grip strength, anthropometry)
- Secondary data
- Self-report questionnaire – paper or computer assisted
- Interviews or focus groups
- None
- Census data
- Healthcare data
- Medical birth registry
- Police & judicial system data
Engagement
Keywords
Consortia and dataset groups
