TLT is a longitudinal study conducted in Balaka, Malawi, designed to examine how young people navigate reproduction in a human immunodeficiency virus (HIV) epidemic. Tsogolo la Thanzi (TLT) means “Healthy Futures” in Chichewa, Malawi’s most widely spoken language. TLT began in 2009 with a population-representative sample of 1,505 women and 574 men between the ages of 15 and 25 living in Balaka, southern Malawi, where regional adult HIV prevalence then stood at 15 percent. The first phase (2009-11) included a series of eight interviews, spaced four months apart. During this time, women's romantic and sexual partners enrolled in the study on an ongoing basis. A refresher sample of 315 women was added in 2012. Seventy-eight percent of respondents were re-interviewed in the second phase of TLT (2015), which consisted of follow-up interviews approximately 3.5 years after the previous interview (ages 21 to 31 years).